Patients taking Wegovy lost an average of 35 lbs (15.9 kg), or about 15% of their body weight compared to 6 lbs (2.7 kg), or roughly 2.5% body weight in the placebo group. Overall, after 68 weeks, 83% of people taking Wegovy lost 5% or more of their weight compared to 31% of people taking a placebo.
Wegovy works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) that targets areas of the brain that regulate appetite and food intake. The medication dose must be increased gradually over 16 to 20 weeks to 2.4 mg once weekly to reduce gastrointestinal side effects.
Wegovy starts working right after you inject a dose. But it may take several weeks or months before you notice weight loss or a decrease in appetite. How long does Wegovy stay in the body? Wegovy stays in the body for about 5 to 7 weeks after the last dose.
If you or a family member have a history of medullary thyroid carcinoma (MTC), you shouldn’t use Wegovy. MTC is a rare type of thyroid cancer. You also shouldn’t use Wegovy if you have multiple endocrine neoplasia syndrome type 2 (MEN2). MEN2 is a rare genetic (inherited) condition that can cause thyroid cancer.